MANF regulates metabolic and immune homeostasis in ageing and protects against liver damage
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NADPH oxidase 4 regulates homocysteine metabolism and protects against acetaminophen-induced liver damage in mice
Glutathione is the major intracellular redox buffer in the liver and is critical for hepatic detoxification of xenobiotics and other environmental toxins. Hepatic glutathione is also a major systemic store for other organs and thus impacts on pathologies such as Alzheimer's disease, Sickle Cell Anaemia and chronic diseases associated with aging. Glutathione levels are determined in part by the ...
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ژورنال
عنوان ژورنال: Nature Metabolism
سال: 2019
ISSN: 2522-5812
DOI: 10.1038/s42255-018-0023-6